Sartel: Advanced Angiotensin II Receptor Blockade Therapy
Sartel
| Product dosage: 40mg | |||
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Sartel is a prescription medication belonging to the class of drugs known as angiotensin II receptor blockers (ARBs). It is primarily indicated for the management of hypertension, offering a targeted mechanism of action that effectively lowers blood pressure by inhibiting the effects of angiotensin II, a potent vasoconstrictor. This medication is designed for long-term cardiovascular risk reduction, aiding in the prevention of stroke, myocardial infarction, and other hypertension-related complications. Its well-tolerated profile and once-daily dosing support adherence and consistent therapeutic outcomes in adult patients.
Features
- Active pharmaceutical ingredient: Telmisartan
- Available in 20mg, 40mg, and 80mg film-coated tablets
- Bioavailability of approximately 42%
- Half-life of approximately 24 hours, enabling once-daily dosing
- Excretion primarily via feces as unchanged compound
- Not significantly metabolized by the cytochrome P450 system
Benefits
- Provides sustained 24-hour blood pressure control with a single daily dose
- Reduces the risk of major cardiovascular events, including stroke and heart attack
- Demonstrates a lower incidence of side effects such as cough compared to ACE inhibitors
- Offers renal protective benefits in patients with type 2 diabetes and hypertension
- Supports vascular health through selective blockade of the AT1 receptor
- May improve endothelial function and reduce arterial stiffness over time
Common use
Sartel is predominantly prescribed for the treatment of essential hypertension in adults, either as monotherapy or in combination with other antihypertensive agents such as thiazide diuretics. It is also indicated to reduce cardiovascular morbidity in patients with manifest atherothrombotic cardiovascular disease or type 2 diabetes mellitus with documented target organ damage. In clinical practice, it is often selected for patients who experience cough with ACE inhibitors or require a well-tolerated, long-acting antihypertensive option. Off-label uses may include management of proteinuria in certain renal conditions, though this should only be undertaken under specialist supervision.
Dosage and direction
The recommended starting dose of Sartel is 40mg taken orally once daily. Dosage may be titrated to 80mg once daily based on individual blood pressure response. In patients with possible depletion of intravascular volume, such as those treated with diuretics, initiation with a 20mg dose is advised. Tablets should be taken with or without food, at approximately the same time each day to maintain consistent plasma levels. For patients with severe hepatic impairment, dosage should not exceed 40mg once daily. The antihypertensive effect is substantially present within two weeks and maximal after four weeks of continuous therapy.
Precautions
Patients should be monitored for symptomatic hypotension, particularly after initiation or dose escalation. Renal function and serum potassium should be assessed periodically, especially in patients with renal impairment, heart failure, or those concurrently using potassium-sparing diuretics, potassium supplements, or salt substitutes containing potassium. Use with caution in patients with bilateral renal artery stenosis or solitary kidney, as acute renal failure may occur. Sartel should not be used during pregnancy due to risk of fetal harm; pregnancy should be excluded before initiation and avoided during therapy. In patients with primary aldosteronism, the drug is not recommended.
Contraindications
Sartel is contraindicated in patients with known hypersensitivity to telmisartan or any component of the formulation. It must not be used concomitantly with aliskiren in patients with diabetes or in patients with renal impairment (GFR <60 mL/min/1.73 m²). Use is contraindicated during the second and third trimesters of pregnancy due to the potential for fetal injury and death. It is also contraindicated in patients with severe hepatic impairment (Child-Pugh class C) due to significantly increased systemic exposure.
Possible side effects
Common adverse reactions (≥1%) include upper respiratory tract infection, back pain, sinusitis, diarrhea, and pharyngitis. Less frequently, dizziness, hypotension, hyperkalemia, and increased serum creatinine may occur. Rare but serious side effects include angioedema, acute renal failure, and symptomatic hypotension. Elevated liver enzymes have been reported, though a causal relationship has not been firmly established. Patients should be advised to report any signs of allergic reaction, such as swelling of the face, lips, or tongue, or difficulty breathing.
Drug interaction
Concomitant use with other RAAS-acting agents (e.g., ACE inhibitors, aliskiren) may increase risks of hypotension, hyperkalemia, and renal impairment. NSAIDs, including selective COX-2 inhibitors, may reduce the antihypertensive effect and increase risk of renal impairment. Lithium levels may increase with concurrent use, necessitating monitoring. Sartel may increase digoxin peak and trough concentrations. Co-administration with ramipril does not appear to affect the pharmacokinetics of either drug, though hemodynamic interactions are possible.
Missed dose
If a dose is missed, it should be taken as soon as remembered on the same day. If it is nearly time for the next dose, the missed dose should be skipped and the regular dosing schedule resumed. Doubling the dose to make up for a missed one is not recommended, as it may increase the risk of hypotension. Patients should be educated on the importance of adherence while reassured that occasional missed doses are unlikely to significantly compromise long-term blood pressure control.
Overdose
The most likely manifestation of overdose is hypotension and tachycardia; bradycardia may occur if vagal stimulation occurs. Should overdose occur, supportive treatment should be instituted, including intravenous normal saline to restore blood pressure. Telmisartan is not removed by hemodialysis due to high protein binding. Close monitoring of vital signs, electrolyte levels, and renal function is essential. Symptomatic treatment should be provided based on clinical presentation.
Storage
Sartel tablets should be stored at room temperature (15–30°C or 59–86°F) in the original container, protected from light and moisture. Keep out of reach of children and pets. Do not use after the expiration date printed on the packaging. Tablets should not be stored in bathrooms or other areas prone to high humidity or temperature fluctuations.
Disclaimer
This information is intended for educational purposes and does not replace professional medical advice, diagnosis, or treatment. Always consult a qualified healthcare provider regarding any questions about a medical condition or medication. Do not disregard professional medical advice or delay seeking it based on content provided here. Dosage, indications, and safety information may change; refer to the latest official prescribing information for current recommendations.
Reviews
Clinical studies and post-marketing surveillance indicate high patient satisfaction with Sartel, particularly regarding its once-daily convenience and low incidence of side effects. Many users report effective blood pressure control without the cough associated with ACE inhibitors. Some patients note mild dizziness during the initial treatment phase, which typically resolves with continued use. Physicians often highlight its metabolic neutrality and cardiovascular protective benefits as key advantages in long-term hypertension management. Overall, it is regarded as a well-tolerated and efficacious option within the ARB class.