Frumil: Effective Dual-Action Diuretic for Edema Management
Frumil
| Product dosage: 5mg+40mg | |||
|---|---|---|---|
| Package (num) | Per pill | Price | Buy |
| 30 | $1.43 | $43.00 (0%) | 🛒 Add to cart |
| 60 | $1.10 | $86.00 $66.00 (23%) | 🛒 Add to cart |
| 90 | $1.06 | $129.00 $95.00 (26%) | 🛒 Add to cart |
| 120 | $1.02 | $172.00 $123.00 (28%) | 🛒 Add to cart |
| 180 | $0.84 | $258.00 $152.00 (41%) | 🛒 Add to cart |
| 270 | $0.68 | $387.00 $184.00 (52%) | 🛒 Add to cart |
| 360 |
$0.56
Best per pill
|
$516.00 $202.00 (61%) | 🛒 Add to cart |
Frumil is a prescription medication combining two potent diuretic agents, furosemide and amiloride, designed for the clinical management of edema associated with congestive heart failure, hepatic cirrhosis, and nephrotic syndrome. This fixed-dose combination leverages complementary mechanisms to promote efficient fluid elimination while mitigating potassium loss, offering a balanced approach to diuretic therapy. It is indicated for patients requiring sustained fluid control where hypokalemia presents a significant concern. Frumil provides a rational therapeutic option under appropriate medical supervision.
Features
- Contains 40 mg furosemide and 5 mg amiloride hydrochloride per tablet
- Dual-action mechanism: loop diuretic and potassium-sparing agent
- Standardized fixed-dose combination for dosing consistency
- Film-coated tablets for ease of administration
- Manufactured under strict pharmaceutical quality standards
- Available in calendar blister packs for compliance support
Benefits
- Promotes effective elimination of excess fluid in edematous conditions
- Reduces risk of hypokalemia through potassium-sparing properties
- May decrease pill burden compared to separate component administration
- Supports management of blood pressure in hypertensive patients with edema
- Can improve functional status in heart failure by reducing cardiac preload
- Provides predictable pharmacokinetics for consistent clinical response
Common use
Frumil is primarily prescribed for the treatment of edema where conservation of potassium is clinically important. This includes edema due to congestive cardiac failure, liver cirrhosis with ascites, and certain renal conditions including nephrotic syndrome. It may also be used as adjunctive therapy in hypertension when other agents require supplementation with a potassium-sparing diuretic. The combination is particularly valuable in patients who develop hypokalemia with furosemide monotherapy or who would benefit from reduced potassium monitoring requirements.
Dosage and direction
The usual adult dosage is one tablet daily, preferably taken in the morning with food to minimize gastrointestinal discomfort. Dosage should be individualized based on therapeutic response and electrolyte balance. In severe cases, two tablets daily may be prescribed under close medical supervision. Tablets should be swallowed whole with a glass of water; they should not be crushed or chewed. Regular monitoring of electrolytes, particularly potassium and sodium, is essential during therapy. Dosage adjustments may be necessary in elderly patients or those with renal impairment.
Precautions
Patients should be monitored for signs of fluid and electrolyte imbalance, including dry mouth, thirst, weakness, lethargy, drowsiness, restlessness, muscle pains or cramps, muscular fatigue, hypotension, oliguria, tachycardia, and gastrointestinal disturbances. Regular assessment of blood pressure, body weight, and renal function is recommended. Caution is advised in patients with diabetes mellitus, gout, or metabolic acidosis. Sun exposure should be limited due to potential photosensitivity reactions. Patients should be advised to rise slowly from sitting or lying positions to prevent orthostatic hypotension.
Contraindications
Frumil is contraindicated in patients with hypersensitivity to furosemide, amiloride, or other sulfonamide-derived drugs. Additional contraindications include anuria, acute renal failure, severe hepatic failure, hyperkalemia (serum potassium >5.5 mEq/L), Addison’s disease, and concurrent use of potassium-sparing diuretics, potassium supplements, or salt substitutes containing potassium. It should not be used during pregnancy unless absolutely necessary, and is generally not recommended while breastfeeding.
Possible side effects
Common side effects may include dizziness, headache, dehydration, electrolyte disturbances (particularly hypokalemia or hyperkalemia), increased blood urea nitrogen, hyperglycemia, and gastrointestinal complaints such as nausea, vomiting, or diarrhea. Less frequently, patients may experience orthostatic hypotension, photosensitivity, rash, impotence, altered libido, tinnitus, hearing impairment, or pancreatitis. Rare but serious adverse effects include blood dyscrasias, severe skin reactions, anaphylactic reactions, and interstitial nephritis. Any unusual symptoms should be reported promptly to a healthcare provider.
Drug interaction
Frumil may interact with numerous medications including: other antihypertensives (additive hypotensive effect); digoxin (altered electrolyte balance may affect toxicity); lithium (increased lithium levels); nonsteroidal anti-inflammatory drugs (reduced diuretic effect); corticosteroids (potentiated hypokalemia); antidiabetic agents (may alter glucose control); aminoglycosides (increased ototoxicity risk); and ACE inhibitors or angiotensin receptor blockers (increased hyperkalemia risk). Patients should inform their physician of all medications, including over-the-counter products and herbal supplements.
Missed dose
If a dose is missed, it should be taken as soon as remembered unless it is nearly time for the next scheduled dose. In that case, the missed dose should be skipped and the regular dosing schedule resumed. Patients should not double the dose to make up for a missed tablet. Consistent daily administration is important for maintaining therapeutic effect, particularly for blood pressure control. Setting a daily reminder or using a pill organizer may help prevent missed doses.
Overdose
Symptoms of overdose may include profound dehydration, electrolyte disturbances (particularly hypokalemia or hyperkalemia), circulatory collapse, thrombotic complications, and cardiac arrhythmias. Gastrointestinal symptoms such as nausea and vomiting may occur. Management involves gastric lavage if ingestion was recent, along with supportive measures including electrolyte correction and fluid replacement. There is no specific antidote; treatment should be symptomatic and supportive. Hemodialysis may remove furosemide but is not effective for amiloride removal. Medical attention should be sought immediately in suspected overdose situations.
Storage
Store at room temperature (15-30°C/59-86°F) in the original container, protected from light and moisture. Keep tightly closed and out of reach of children. Do not use after the expiration date printed on the packaging. Tablets should not be stored in bathrooms or other areas with high humidity. Proper disposal of unused medication is important to prevent accidental ingestion or environmental contamination.
Disclaimer
This information is provided for educational purposes only and does not constitute medical advice. Frumil is a prescription medication that should be used only under the supervision of a qualified healthcare professional. Individual response to therapy may vary, and only a physician can determine the appropriate treatment based on specific medical circumstances. Patients should not initiate, discontinue, or change dosage without medical consultation.
Reviews
Clinical studies have demonstrated Frumil’s efficacy in maintaining potassium balance while providing effective diuresis. In comparative trials, the combination showed superior potassium conservation compared to furosemide alone, with comparable fluid elimination. Many physicians report satisfactory edema control with reduced monitoring requirements in appropriate patient populations. Some studies note the fixed-dose nature may limit dosing flexibility in patients requiring precise titration. Overall, Frumil represents a valuable option for patients requiring combination diuretic therapy with potassium conservation.