Aceon: Advanced Blood Pressure Control with Perindopril
Aceon
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| 360 |
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| Product dosage: 4mg | |||
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| Product dosage: 8mg | |||
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Synonyms
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Aceon (perindopril erbumine) is an angiotensin-converting enzyme (ACE) inhibitor prescribed for the management of hypertension and stable coronary artery disease. This medication works by relaxing blood vessels, allowing blood to flow more smoothly and the heart to pump more efficiently. Clinical evidence supports its use in reducing cardiovascular events in appropriate patient populations. Proper administration under medical supervision is essential for achieving optimal therapeutic outcomes while minimizing risks.
Features
- Active ingredient: Perindopril erbumine
- Available in 2 mg, 4 mg, and 8 mg tablet strengths
- Once-daily oral dosing regimen
- ACE inhibitor class medication
- FDA-approved for hypertension and coronary artery disease
Benefits
- Effectively lowers high blood pressure, reducing strain on the cardiovascular system
- Decreases risk of heart attack, stroke, and other cardiovascular events in patients with established coronary artery disease
- Helps protect kidney function in hypertensive patients, particularly those with diabetes
- Improves overall cardiac output and exercise tolerance in heart failure patients
- May slow progression of atherosclerosis in appropriate patient populations
- Provides 24-hour blood pressure control with single daily dosing
Common use
Aceon is primarily prescribed for the treatment of hypertension, either as monotherapy or in combination with other antihypertensive agents. It is also indicated to reduce the risk of cardiovascular mortality and nonfatal myocardial infarction in patients with stable coronary artery disease. Additionally, clinicians may prescribe Aceon for off-label uses including heart failure management and diabetic nephropathy prophylaxis, based on individual patient assessment and clinical judgment.
Dosage and direction
The recommended initial dose for hypertension is 4 mg once daily, which may be increased to 8 mg once daily after at least two weeks of therapy. For elderly patients or those with renal impairment, starting with 2 mg once daily is advised. Dosage should be titrated based on blood pressure response and tolerability. The maximum recommended daily dose is 16 mg. For cardiovascular risk reduction in stable coronary artery disease, the recommended maintenance dose is 8 mg once daily. Tablets should be taken orally, with or without food, at approximately the same time each day.
Precautions
Patients should be monitored for hypotension, especially during initial dosing and dose escalation. Renal function and serum potassium should be assessed prior to initiation and periodically during therapy. ACE inhibitors may cause injury or death to the developing fetus; discontinue immediately if pregnancy is detected. Use with caution in patients with renal impairment, collagen vascular disease, or those taking potassium supplements or potassium-sparing diuretics. Angioedema may occur at any time during treatment and requires immediate medical attention.
Contraindications
Aceon is contraindicated in patients with a history of angioedema related to previous ACE inhibitor therapy. It should not be used in patients with hereditary or idiopathic angioedema. Concomitant use with aliskiren in patients with diabetes is contraindicated. Do not administer to patients with hypersensitivity to perindopril or any component of this medication. Avoid use in patients taking neprilysin inhibitors.
Possible side effect
Common adverse reactions include cough, dizziness, headache, fatigue, and gastrointestinal disturbances. Less frequently, patients may experience orthostatic hypotension, hyperkalemia, rash, or taste disturbance. Serious side effects requiring immediate medical attention include angioedema, hepatotoxicity, neutropenia/agranulocytosis, and renal impairment. The incidence of cough is higher in women and non-smokers.
Drug interaction
Concomitant use with diuretics may potentiate hypotensive effects. NSAIDs may reduce the antihypertensive effect and increase risk of renal impairment. Potassium supplements or potassium-sparing diuretics may increase risk of hyperkalemia. Lithium levels may increase when co-administered with ACE inhibitors. Dual blockade of the renin-angiotensin system with ARBs or aliskiren increases risk of renal impairment, hyperkalemia, and hypotension.
Missed dose
If a dose is missed, it should be taken as soon as remembered unless it is nearly time for the next scheduled dose. In that case, skip the missed dose and resume the regular dosing schedule. Do not double the dose to make up for a missed dose. Patients should be educated on maintaining consistent dosing to ensure optimal blood pressure control.
Overdose
Symptoms of overdose may include severe hypotension, bradycardia, circulatory shock, electrolyte disturbances, and renal failure. Management involves supportive care including volume expansion with normal saline. Perindopril may be removed from the circulation by hemodialysis. Patients should be monitored in an intensive care setting with continuous blood pressure and ECG monitoring.
Storage
Store at room temperature (20-25°C or 68-77°F) in the original container. Protect from moisture and light. Keep tightly closed and out of reach of children. Do not use after the expiration date printed on the packaging. Do not transfer tablets to other containers as this may affect stability.
Disclaimer
This information is for educational purposes only and does not constitute medical advice. Aceon should only be used under the supervision of a qualified healthcare professional. Patients should not make any changes to their medication regimen without consulting their physician. The prescribing information provided here may not include all possible uses, directions, precautions, or interactions.
Reviews
Clinical studies demonstrate Aceon’s efficacy in blood pressure control with once-daily dosing convenience. The EUROPA trial showed significant reduction in cardiovascular events in patients with stable coronary artery disease. Many patients report satisfactory blood pressure management with minimal side effects, though the characteristic ACE inhibitor cough remains a consideration in treatment decisions. Healthcare providers appreciate its predictable pharmacokinetics and established safety profile in appropriate patient populations.